Drug Resistance and its Solution in Chemotherapy of Gynecologic Malignant Tumors
نویسندگان
چکیده
Drug resistance is the fundamental reason for tumor recurrence and treatment failure in gynecologic malignant tumors. Drug resistance prevention requires familiarity with physicochemical properties of chemotherapeutic drugs, characteristics of vivo metabolism, correctly chosen chemotherapeutic schemes including multi-drug combination chemotherapy, experimental for doubtful diagnosis and timely assessment to find, treat and prevent serious toxic side effects. Patients should receive sufficient and timely normative chemotherapy as early as possible.
منابع مشابه
بررسی روشهای تشخیص و درمان سارکومهای رحمی: مقاله مروری
Uterine sarcomas comprise a group of rare tumors with different tumor biology, natural history and response to treatment, contain just 3-7% of total uterine malignancies and about 1% of all gynecologic cancers. Although they cause important part of women death due gynecologic cancers. These tumors have aggressive behavior and high recurrence rate, even when confined to the uterine corpus at the...
متن کاملTypes and frequency of ovarian masses in children over a 10-year period
Background: Ovarian masses represent a range of pathology from benign cyst to highly aggressive malignant tumors. It has been estimated that gynecologic malignancy account for approximately 2% of all types of cancer in children, 60-70% of these lesions arise in the ovary. Methods: All ovarian masses which were resected or biopsied in Mofid Children's Hospital from 2002 to 2012 were reviewe...
متن کاملتأثیر آدنوزین ´5تری فسفات در القای آپوپتوز و مهار بیان ژن Survivin و واریانت پیرایشی ضد آپوپتوزی SUR-3B آن در سلول های K562
Introduction: Leukemia is a heterogeneous malignant disease in which progression at the level of CD34+ cells has a major impact in drug resistance and relapse. The multi-drug resistance gene product, P-glycoprotein is an inhibitor of apoptosis proteins (IAPs), such as Survivin that are expressed simultaneously with several putative drug resistance parameters in CD34+ leukemia cells. In fact, IA...
متن کاملPrimary Malignant Lymphoma of Cervix: A Case Report
Background:Primary malignant lymphoma of the uterine cervix is extremely rare and can be misdiagnosed due to its different clinical presentations. The aim of this report was to introduce a case of primary malignant lymphoma of the uterine cervix which was misdiagnosed as an ovarian cyst on ultrasonography. Case report: A 31-year-old female referred with a...
متن کاملDetection of Survivin Gene Expression in Formalin-Fixed Paraffin-Embedded Tissues of Human Osteosarcoma: Its Potential Usefulness in Diagnosis and Prognosis of Bone Tumors
Osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. Diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. Survivin, an inhibitor of apoptosis (IAP), is unique for its expression in human tumors ...
متن کامل